Titel der Studie: Prolonged multimodal fasting modulates periodontal inflammation in female patients with metabolic syndrome: A prospective cohort study
von Pappe CL, Steckhan N, Hoedke D, Jepsen S, Rauch G, Keller T, Michalsen A, Dommisch H. (2021)
Aim: To determine the potential anti-inflammatory effect of a multimodal periodic fasting programme on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS).
Material and methods: A total of 47 patients were recruited and hospitalized in an integrative ward for an intensified two-week multimodal fasting, diet and lifestyle programme. Patients were periodontally examined at baseline (t1), after the 2-week fasting protocol (t2) and, subsequently, 4 months after fasting (t3). The following parameters were determined: periodontal screening index (PSI), bleeding on probing (BOP), gingival crevicular fluid volume (GCF), plaque index (PI), C-reactive protein (CRP), blood pressure (BP), waist circumference (WC), fasting glucose (FGLU), triglycerides (TRG), high-density lipoprotein (HDL) and HbA1c.
Results: A total of 28 female and 8 male patients fulfilled the defined criteria for MetS and were analysed separately by gender. At t2, BOP and GCF were reduced when compared to t1 (median: t2 = 39; t1 = 33.1%; p < .001 and t2 = 73.9; t1 = 59.3 Periotron units p = .02, respectively). BOP reduction correlated to FGLU (R = .37, p = .049) and weight reduction (R = .4, p = .04).
Conclusion: This study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.
Keywords: C-reactive protein; bleeding on probing; fasting; gingival crevicular fluid; metabolic syndrome; periodontal inflammation.
© 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
Pappe CL, Steckhan N, Hoedke D, Jepsen S, Rauch G, Keller T, Michalsen A, Dommisch H. Prolonged multimodal fasting modulates periodontal inflammation in female patients with metabolic syndrome: A prospective cohort study. J Clin Periodontol. 2021 Apr;48(4):492-502. doi: 10.1111/jcpe.13419